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DMP 543

CAS No. 160588-45-4

DMP 543( XR-543 | XR 543 | DMP-543 )

Catalog No. M12308 CAS No. 160588-45-4

A potent blocker of voltage-gated potassium channels Kv7 (KCNQ) that enhances ACh release from rat hippocampal slices in vitro with EC50 of 0.7 uM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    DMP 543
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent blocker of voltage-gated potassium channels Kv7 (KCNQ) that enhances ACh release from rat hippocampal slices in vitro with EC50 of 0.7 uM.
  • Description
    A potent blocker of voltage-gated potassium channels Kv7 (KCNQ) that enhances ACh release from rat hippocampal slices in vitro with EC50 of 0.7 uM; maintains the 5- to 10-fold potency differential over linopirdine in increasing extracellular hippocampal ACh levels in the rat with a minimum effective dose of 1 mg/kg.Alzheimer Disease Phase 2 Discontinued.
  • In Vitro
    DMP-543 enhances [3H]ACh release from rat brain slices, with an EC50 of 700 nM.
  • In Vivo
    ——
  • Synonyms
    XR-543 | XR 543 | DMP-543
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Potassium Channel
  • Research Area
    Neurological Disease
  • Indication
    Alzheimer Disease

Chemical Information

  • CAS Number
    160588-45-4
  • Formula Weight
    412.44
  • Molecular Formula
    C26H18F2N2O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (242.47 mM)
  • SMILES
    O=C1C2=C(C=CC=C2)C(CC3=CC(F)=NC=C3)(CC4=CC(F)=NC=C4)C5=CC=CC=C15
  • Chemical Name
    10,10-bis[(2-Fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Earl RA, et al. J Med Chem. 1998 Nov 5;41(23):4615-22. 2. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30. 3. Pesti JA, et al. J Org Chem. 2000 Nov 17;65(23):7718-22. 4. Ipavec V, et al. Pharmacol Res. 2011 Oct;64(4):397-409.
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