DMP 543
CAS No. 160588-45-4
DMP 543 ( XR-543;XR 543;DMP-543 )
Catalog No. M12308 CAS No. 160588-45-4
A potent blocker of voltage-gated potassium channels Kv7 (KCNQ) that enhances ACh release from rat hippocampal slices in vitro with EC50 of 0.7 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 58 | Get Quote |
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10MG | 87 | Get Quote |
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25MG | 205 | Get Quote |
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50MG | 335 | Get Quote |
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100MG | 500 | Get Quote |
|
200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameDMP 543
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NoteResearch use only, not for human use.
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Brief DescriptionA potent blocker of voltage-gated potassium channels Kv7 (KCNQ) that enhances ACh release from rat hippocampal slices in vitro with EC50 of 0.7 uM.
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DescriptionA potent blocker of voltage-gated potassium channels Kv7 (KCNQ) that enhances ACh release from rat hippocampal slices in vitro with EC50 of 0.7 uM; maintains the 5- to 10-fold potency differential over linopirdine in increasing extracellular hippocampal ACh levels in the rat with a minimum effective dose of 1 mg/kg.Alzheimer Disease Phase 2 Discontinued
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SynonymsXR-543;XR 543;DMP-543
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorPotassium Channel
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Research AreaNeurological Disease
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IndicationAlzheimer Disease
Chemical Information
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CAS Number160588-45-4
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Formula Weight412.44
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Molecular FormulaC26H18F2N2O
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1C2=C(C=CC=C2)C(CC3=CC(F)=NC=C3)(CC4=CC(F)=NC=C4)C5=CC=CC=C15
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Chemical Name10,10-bis[(2-Fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Earl RA, et al. J Med Chem. 1998 Nov 5;41(23):4615-22.
2. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30.
3. Pesti JA, et al. J Org Chem. 2000 Nov 17;65(23):7718-22.
4. Ipavec V, et al. Pharmacol Res. 2011 Oct;64(4):397-409.
2. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30.
3. Pesti JA, et al. J Org Chem. 2000 Nov 17;65(23):7718-22.
4. Ipavec V, et al. Pharmacol Res. 2011 Oct;64(4):397-409.
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